Vincristine polyneuropathy in children with acute lymphoblastic leukemia: the association with the hereditary rs924607 polymorphism in the <i>CEP72</i> gene

Background: Vincristine polyneuropathy is a major neurotoxic complication of treatment for acute lymphoblastic leukemia in children. A close relationship between genetic variants candidate genes associated with the vincristine neurotoxicity various ethnic groups has been proposed. Therefore, identification risk factors underlying predisposition to could allow development effective tools preventive diagnostics aimed at identifying high-risk group among patients treated personalized approach their chemotherapy.
 Aim: To study an association rs924607 polymorphism CEP72 gene and children leukemia.
 Materials methods: This single center cohort enrolled 199 aged 3 17 years newly diagnosed leukemia, who received ALL-MB 2015 chemotherapy regimen. All were genotyped nucleotide variant by real-time polymerase chain reaction subsequent allelic discrimination. comparative analysis incidence clinical signs depending on carrier was performed.
 Results: The pediatric 81.0% (n = 161); mostly these NCI-STCAE grade 2 severity. significantly complication, 19.1% 38) homozygous minor allele (rs924607 genotype TT) 46.2% 92) had ST genotype. Among carriers least one (T), odds ratio 2.91 (95% confidence interval 1.415.99, p 0.004). No significant assessed vincristine-induced found.
 Conclusion: gen can be putative pharmacogenetic marker polyneuropathy.